Pestalactams A-C: Novel caprolactams from the endophytic fungus Pestalotiopsis spExport / Share Share this record       Export this recordPlumX View Altmetrics View AltmetricsDavis, R. A., Carroll, A. R., Andrews, K. T., Boyle, G. M., Tran, T. L., Healy, P. C., Kalaitzis, J. A. and Shivas, R. G. (2010) Pestalactams A-C: Novel caprolactams from the endophytic fungus Pestalotiopsis sp. Organic and Biomolecular Chemistry, 8 (8). pp. 1785-1790. ISSN 14770520 (ISSN) Full text not currently attached. Access may be available via the Publisher's website or OpenAccess link. Article Link: https://doi.org/10.1039/b924169h AbstractChemical investigations of a fermentation culture from the endophytic fungus Pestalotiopsis sp. yielded three novel caprolactams, pestalactams A-C (1-3). The structures of 1-3 were determined by analysis of 1D and 2D-NMR, UV, IR, and MS data. The structure of pestalactam A was confirmed following single crystal X-ray diffraction analysis. Pestalactams A-C are the first C-7 alkylated caprolactam natural products to be reported. Pestalactams A (1) and B (2) were tested against two different strains of the malaria parasite Plasmodium falciparum (3D7 and Dd2), and the mammalian cell lines, MCF-7 and NFF, and showed modest in vitro activity in all assays. © 2010 The Royal Society of Chemistry.
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