Centromeres are hotspots for chromosomal inversions and breeding traits in mangoExport / Share PlumX View Altmetrics View AltmetricsWilkinson, M. J., McLay, K., Kainer, D., Elphinstone, C., Dillon, N. L., Webb, M., Wijesundara, U. K., Ali, A., Bally, I. S.E., Munyengwa, N., Furtado, A., Henry, R. J., Hardner, C. M. and Ortiz-Barrientos, D. (2024) Centromeres are hotspots for chromosomal inversions and breeding traits in mango. New Phytologist, 246 (2). pp. 899-913. ISSN 0028-646X Full text not currently attached. Access may be available via the Publisher's website or OpenAccess link. Article Link: https://doi.org/10.1111/nph.20252 Article URL: https://www.biorxiv.org/content/10.1101/2024.05.09.593432v1.full.pdf AbstractChromosomal inversions can preserve combinations of favorable alleles by suppressing recombination. Simultaneously, they reduce the effectiveness of purifying selection enabling deleterious alleles to accumulate. This study explores how areas of low recombination, including centromeric regions and chromosomal inversions, contribute to the accumulation of deleterious and favorable loci in 225 Mangifera indica genomes from the Australian Mango Breeding Program. Here, we identify 17 chromosomal inversions that cover 7.7% (29.7 Mb) of the M. indica genome: eight pericentric (inversion includes the centromere) and nine paracentric (inversion is on one arm of the chromosome). Our results show that these large pericentric inversions are accumulating deleterious loci, while the paracentric inversions show deleterious levels above and below the genome wide average. We find that despite their deleterious load, chromosomal inversions contain small effect loci linked to variation in crucial breeding traits. These results indicate that chromosomal inversions have likely facilitated the evolution of key mango breeding traits. Our study has important implications for selective breeding of favorable combinations of alleles in regions of low recombination.
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