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Centromeres are hotspots for chromosomal inversions and breeding traits in mango

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Wilkinson, M. J., McLay, K., Kainer, D., Elphinstone, C., Dillon, N. L., Webb, M., Wijesundara, U. K., Ali, A., Bally, I. S.E., Munyengwa, N., Furtado, A., Henry, R. J., Hardner, C. M. and Ortiz-Barrientos, D. (2024) Centromeres are hotspots for chromosomal inversions and breeding traits in mango. New Phytologist, 246 (2). pp. 899-913. ISSN 0028-646X

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Article Link: https://doi.org/10.1111/nph.20252

Article URL: https://www.biorxiv.org/content/10.1101/2024.05.09.593432v1.full.pdf

Abstract

Chromosomal inversions can preserve combinations of favorable alleles by suppressing recombination. Simultaneously, they reduce the effectiveness of purifying selection enabling deleterious alleles to accumulate. This study explores how areas of low recombination, including centromeric regions and chromosomal inversions, contribute to the accumulation of deleterious and favorable loci in 225 Mangifera indica genomes from the Australian Mango Breeding Program. Here, we identify 17 chromosomal inversions that cover 7.7% (29.7 Mb) of the M. indica genome: eight pericentric (inversion includes the centromere) and nine paracentric (inversion is on one arm of the chromosome). Our results show that these large pericentric inversions are accumulating deleterious loci, while the paracentric inversions show deleterious levels above and below the genome wide average. We find that despite their deleterious load, chromosomal inversions contain small effect loci linked to variation in crucial breeding traits. These results indicate that chromosomal inversions have likely facilitated the evolution of key mango breeding traits. Our study has important implications for selective breeding of favorable combinations of alleles in regions of low recombination.

Item Type:Article
Corporate Creators:Department of Agriculture and Fisheries, Queensland
Business groups:Horticulture and Forestry Science
Subjects:Science > Botany > Genetics
Plant culture > Food crops
Plant culture > Fruit and fruit culture
Live Archive:26 Nov 2024 02:59
Last Modified:31 Jan 2025 01:39

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