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Pestalactams A-C: Novel caprolactams from the endophytic fungus Pestalotiopsis sp

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Davis, R. A., Carroll, A. R., Andrews, K. T., Boyle, G. M., Tran, T. L., Healy, P. C., Kalaitzis, J. A. and Shivas, R. G. (2010) Pestalactams A-C: Novel caprolactams from the endophytic fungus Pestalotiopsis sp. Organic and Biomolecular Chemistry, 8 (8). pp. 1785-1790. https://doi.org/10.1039/b924169h

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Article Link: https://doi.org/10.1039/b924169h

Abstract

Chemical investigations of a fermentation culture from the endophytic fungus Pestalotiopsis sp. yielded three novel caprolactams, pestalactams A-C (1-3). The structures of 1-3 were determined by analysis of 1D and 2D-NMR, UV, IR, and MS data. The structure of pestalactam A was confirmed following single crystal X-ray diffraction analysis. Pestalactams A-C are the first C-7 alkylated caprolactam natural products to be reported. Pestalactams A (1) and B (2) were tested against two different strains of the malaria parasite Plasmodium falciparum (3D7 and Dd2), and the mammalian cell lines, MCF-7 and NFF, and showed modest in vitro activity in all assays. © 2010 The Royal Society of Chemistry.

Item Type:Article
Business groups:Biosecurity Queensland
Keywords:Endophytic fungi Fermentation culture In-vitro Malaria parasite Mammalian cell lines Natural products Plasmodium falciparum Single crystal X-ray diffraction analysis Animal cell culture Cell culture Crystal structure Fungi Mammals Single crystals X ray diffraction X ray diffraction analysis antimalarial agent caprolactam animal article Ascomycetes cell line cell proliferation chemical structure chemistry drug effect fermentation human isolation and purification metabolism tumor cell line Animals Antimalarials Ascomycota Cell Line, Tumor Humans Models, Molecular Mammalia Pestalotiopsis sp.
Subjects:Science > Botany > Cryptogams
Agriculture > Agriculture (General) > Agricultural chemistry. Agricultural chemicals
Live Archive:17 Jan 2023 04:02
Last Modified:06 Dec 2024 05:08

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