Vaccine Adjuvants: Efficient and Durable Vaccine against Intimin β of Diarrheagenic E. Coli Induced by Clay NanoparticlesExport / Share Share this record       Export this recordPlumX View Altmetrics View AltmetricsChen, W., Zhang, B., Mahony, T., Gu, W., Rolfe, B. and Xu, Z. P. (2016) Vaccine Adjuvants: Efficient and Durable Vaccine against Intimin β of Diarrheagenic E. Coli Induced by Clay Nanoparticles. Small, 12 (12). p. 1541. ISSN 1613-6829 Full text not currently attached. Access may be available via the Publisher's website or OpenAccess link. Article Link: http://dx.doi.org/10.1002/smll.201670058 AbstractOn page 1627, layered double hydroxide (hexagonal) and hectorite (sheet) nanoparticles are demonstrated to be promising vaccine adjuvants by T. Mahony, Z. P. Xu, and co-workers. The nanoparticles induce sustained, high levels of specific antibodies (IgG and IgA) and a strong cell-mediated response (IFN-γ), in comparison with the commonly-used adjuvant QuilA. Their high adjuvanticity could be attributed to the high antigen loading, facilitation to the antigen cellular uptake and the depot effect.
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