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Amelioration of virulent Babesia bovis infection in calves by administration of the nitric oxide synthase inhibitor aminoguanidine

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Gale, K.R., Waltisbuhl, D.J., Bowden, J.M., Jorgensen, W.K., Matheson, J., East, I.J., Zakrzewski, H. and Leatch, G. (1998) Amelioration of virulent Babesia bovis infection in calves by administration of the nitric oxide synthase inhibitor aminoguanidine. Parasite Immunology, 20 (9). pp. 441-445. ISSN 1365-3024

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Article Link: https://doi.org/10.1046/j.1365-3024.1998.00169.x

Abstract

Calves undergoing initial infection with a virulent strain of the haemoprotozoan parasite Babesia bovis were treated with aminoguanidine (AG), an inhibitor of the inducible form of nitric oxide synthase (iNOS). The mean maximum parasitaemia of the AG treated calves was significantly lower than that of the control cattle. In addition, the febrile response and decrease in packed cell volume (PCV) observed during acute infection were significantly ameliorated in the AG treated cattle relative to the controls. However, AG had no effect on the multiplication of B. bovis in the microaerophilous stationary-phase (MASP) in-vitro culture system. These results provide evidence of a role for nitric oxide (NO) produced in response to acute infection in the pathology of bovine babesiosis.

Item Type:Article
Subjects:Science > Microbiology > Immunology
Veterinary medicine > Veterinary parasitology
Veterinary medicine > Diseases of special classes of animals > Cattle
Live Archive:17 Mar 2024 23:32
Last Modified:17 Mar 2024 23:32

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